Effervescent citric-acid-hexamethylene-tetramin tablet.



f UNITED ST TES. PATENT OFFICE.

nnmarcn artisan, or 3mm. Germany, nssIeNoa ,rc JOHANN ABRAHAM you wtmrmaor BERLIN, GERMANY.

nrrnnvascnnr crrmc-ncrn-HaxAMETHYLENE-rrmanna TABLET.

No Drawing.

Specification of ietters' ratent. Application filed July 20, 1912. Serial No. 710,685.

PatentedJuly 1,1913.

i To all whom it may concern:

Be it known that I, V doctor of chemistry, a citizen of the Em ire of Germany, residing1 at Berlin, inthe *mpire of Germany, ave invented a new and useful Effervescent Citric-Acid-Hexamethylene-Tetramin Tablet, of which the following is a specification.

My inventionconsists in a method of producing durable. effervescent ,Itablets from citric acid and hexamethylene-tetramin, which may either be simply mixed together or chemically combined, the said tablets being useful both as a bladder disinfectant and as a diuretic.

' I will now proceed to describe my invention.

The citric acid and the hexamethylenetetramin, which may be either simply mixed or chemically combined, are mixed with a mixture of alkali carbonate and anhydrous sodium acetate formed into tablets in any known manner; The tablets are preserved in tubes closed with metallic capsules or corked, and remain erman'entlyundecomposed in rooms of ordinary de ree of moisture. veg easily solu 1c in water, while'carbonic aci separates, and the water shows an agreeable and sourish refreshin taste. The a1- kali carbonate ma be so ium bicarbonate or= water free so a. The acetate of sodium presents the important advantage, that it supports the disinfecting efiect of -Hnimucrr UMBER,

the hexamethylene-tetramin, since it is itself andallowing the first precipitated mass to stand for a long time over ice, until it hardens into a mass of crystalline needles. This is a white salt, which is easily soluble in warm water, also in methyl-alcohol, and

in warm ethyl-alcohol, and melts at 105 to 106 centigrade. The crystallized citricacid' hexamethylene-tetramin may also be produced without the surplus of alcohol in and the resulting mass isv They aremass of crystals the manner, that the citric acid alone is added to the concentrated aqueous solution of hexamethylene-tetramin and the solution is inoculated by contact with a small quantity of crystals obtained in previous operations, whereby any quantity in the crystalline form instead of 1n the syrupy state can be obtained.

When the mixture of citric acid and hexamethylenertetramin or the above mentioned crystallized citric acid hexamethylene tetramin is mixed with sodium bicarbonate or sodium-carbonate alone, carbonic acid will be liberated on keeping, so that the tablets formed from this mixture would not be durable. The same result would follow, if the said components were mixed Withi soda salt free from wateralone; it is therefore essential to add the anhydrous acetate of sodiumfor the reason given above.

Following are a few examples of the manufacture Example 1: 2 kilograms -'of finely powdered hexamethylene-tetramin are mixed with 3 kilograms of finely powdered citric acid, to the perfectly dry mixture are then added 1.5 kilograms of soda free from water and 2.4 kilograms of anhydrous acetate of ,SOdlllIIl, after which the mass is formed into tablets.

Exam le 2: 3 kilograms of citric acid are dissolve in 5.4 liters of alcohol of 96% and this solution is mixed solution of 2 kilograms of hexamethylenetetramin in 2.9 liters of water. Then the solution obtained is inoculated with a small quantity of the crystallized compound obtained by a previous operation. After standing over me for one day the mass of crystals separated amounts to abou't'95% of the theoretical quantity. The separated is then dried and is mixed with a mixture of 1.36 kilograms of anhydrous sodium carbonate and 2.17 kilograms of anhydrous sodium acetate. From 'the resulting mixture tablets are'formed.

Example 3:2 kilograms of hexamethylone-tetramin are dissolved in 2.9 liters of water, and to the solution formed '3 kilograms of powdered citric acid are added, whereupon firstly the entire citric acid is dissolved. Then the liquid is inoculated with a small quantity of the crystallized compound obtained bya previous reaction. After a certaintime the crystallization comwith an aqueous mences with a rise of temperature which crystallization. is aided by cooling. The 7 crystals formed are separated by filtration and the separated mass 1s dried, next it is mixed with-a mixture of 1.86 kilograms of anhydrouss odium carbonate and 2.17 kilograms of aiihydrous sodium acetate, and the I resulting mixture is formed into tablets.

I claim:

10 The herein described efier'vescent medicinaltablet consisting of citric acid; hexamethylene-tetramin, an alkali carbonate and anhydrous-sodium acetate.

In testimony whereof I afiixmy signature in presence of two witnesses;

Witnesses: a

FRITZ QUADE, 1 EBERHARD THIELEMANN.

HEINRICH UliiBERQ'} 

